Article
A novel P755L mutation in LRRK2 gene associated with Parkinson's disease.
Neuroreport - 18 Dec 2006
Wu Ting, Zeng Yanying, Ding Xinsheng, Li Xiaobo, Li Wenlei, Dong Hairong, Chen Senqing, Zhang Xiaomei, Ma Guojian, Yao Juan, Deng Xiaoxuan
Abstract excerpt
Parkinson's disease is a common neurodegenerative disorder. The identification of leucine-rich repeat kinase 2 (LRRK2) gene mutations as a cause of Parkinson's disease has greatly expanded our knowledge of the genetic and molecular pathogenesis of this disorder. By denaturing high-performance liquid chromatography and gene sequencing in patients and controls, we identified a novel frequent heterozygous 2264C-->T...
Topics
- Adult
- Aged
- Aged, 80 and over
- DNA Mutational Analysis
- Female
- Gene Frequency
- Genetic Predisposition to Disease
- Genotype
- Humans
- Leucine
- Leucine-Rich Repeat Serine-Threonine Protein Kinase-2