Article
Genetic analysis of LRRK2 P755L variant in Caucasian patients with Parkinson's disease.
Neuroscience letters - 29 May 2007
Deng Hao, Le Weidong, Huang Maosheng, Xie Wenjie, Pan Tianghong, Jankovic Joseph
Abstract excerpt
Parkinson's disease (PD) is the second most common neurodegenerative disease with major clinical features of bradykinesia, rigidity, resting tremor, and postural instability. Mutations in the leucine-rich repeat kinase 2 gene (LRRK2) have been identified both in familial and sporadic cases of PD. Recently, a P755L variant in the LRRK2 gene has been found to be responsible for 2% of Chinese patients with sporadic...
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