Article
LRRK2 P755L variant in sporadic Parkinson's disease.
Journal of human genetics - 1 Jan 2008
Tomiyama Hiroyuki, Mizuta Ikuko, Li Yuanzhe, Funayama Manabu, Yoshino Hiroyo, Li Lin, Murata Miho, Yamamoto Mitsutoshi, Kubo Shin-Ichiro, Mizuno Yoshikuni, Toda Tatsushi, Hattori Nobutaka
Abstract excerpt
Parkinson's disease (PD) is a neurodegenerative disorder of unknown etiology with probable involvement of genetic-environmental factors. The majority of PD cases (approximately 90-95%) are sporadic, while familial cases account for approximately 5-10% of PD. In a recent report, a heterozygous LRRK2 P755L mutation within LRRK2 exon 19 was found in 2% of Chinese sporadic PD patients and in 0% of normal controls or...
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