Article
Genetic screening for a single common LRRK2 mutation in familial Parkinson's disease.
Lancet (London, England) - 1 Jan 2000
Nichols William C, Pankratz Nathan, Hernandez Dena, Paisán-Ruíz Coro, Jain Shushant, Halter Cheryl A, Michaels Veronika E, Reed Terry, Rudolph Alice, Shults Clifford W, Singleton Andrew, Foroud Tatiana
Abstract excerpt
Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene cause some forms of autosomal dominant Parkinson's disease. We measured the frequency of a novel mutation (Gly2019 ser) in familial Parkinson's disease by screening genomic DNA of patients and controls. Of 767 affected individuals from 358 multiplex families, 35 (5%) individuals were either heterozygous (34) or homozygous (one) for the mutation, and had...
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