Article
Genetic screening for a single common LRRK2 mutation in familial Parkinson's disease.
Lancet (London, England) - 1 Jan 2000
Nichols William C, Pankratz Nathan, Hernandez Dena, Paisán-Ruíz Coro, Jain Shushant, Halter Cheryl A, Michaels Veronika E, Reed Terry, Rudolph Alice, Shults Clifford W, Singleton Andrew, Foroud Tatiana
Abstract excerpt
Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene cause some forms of autosomal dominant Parkinson's disease. We measured the frequency of a novel mutation (Gly2019 ser) in familial Parkinson's disease by screening genomic DNA of patients and controls. Of 767 affected individuals from 35...
Topics
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Genetic Predisposition to Disease
- Genetic Testing
- Genotype
- Heterozygote
- Homozygote
- Humans
- Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
- Male
- Middle Aged
- Parkinson Disease