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Article

Transglutaminase 2 undergoes a large conformational change upon activation.

PLoS biology - 1 Dec 2007

Pinkas Daniel M, Strop Pavel, Brunger Axel T, Khosla Chaitan

Abstract excerpt

Human transglutaminase 2 (TG2), a member of a large family of enzymes that catalyze protein crosslinking, plays an important role in the extracellular matrix biology of many tissues and is implicated in the gluten-induced pathogenesis of celiac sprue. Although vertebrate transglutaminases have been studied extensively, thus far all structurally characterized members of this family have been crystallized in...

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Identifiers

PMID: 18092889
DOI: 10.1371/journal.pbio.0050327
PMCID: PMC2140088

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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