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The Biological and Biomechanical Role of Transglutaminase-2 in the Tumour Microenvironment

3 Jun 2021

Abstract excerpt

Transglutaminase-2 (TG2) is the most highly and ubiquitously expressed member of the transglutaminase enzyme family and is primarily involved in protein cross-linking. TG2 has been implicated in the development and progression of numerous cancers, with a direct role in multiple cellular processes and pathways linked to apoptosis, chemoresistance, epithelial-mesenchymal transition, and stem cell phenotype. The...

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PMID: 34205140
DOI: 10.3390/cancers13112788

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