Regulation of proto-oncogenic dbl by chaperone-controlled, ubiquitin-mediated degradation.

Abstract excerpt

The dbl proto-oncogene product is a prototype of a growing family of guanine nucleotide exchange factors (GEFs) that stimulate the activation of small GTP-binding proteins from the Rho family. Mutations that result in the loss of proto-Dbl's amino terminus produce a variant with constitutive GEF activity and high oncogenic potential. Here, we show that proto-Dbl is a short-lived protein that is kept at low levels...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Guanine Nucleotide Exchange Factors
• Share to HSC70 Heat-Shock Proteins