Article
ARD1-mediated Hsp70 acetylation balances stress-induced protein refolding and degradation.
Nature communications - 6 Oct 2016
Seo Ji Hae, Park Ji-Hyeon, Lee Eun Ji, Vo Tam Thuy Lu, Choi Hoon, Kim Jun Yong, Jang Jae Kyung, Wee Hee-Jun, Lee Hye Shin, Jang Se Hwan, Park Zee Yong, Jeong Jaeho, Lee Kong-Joo, Seok Seung-Hyeon, Park Jin Young, Lee Bong Jin, Lee Mi-Ni, Oh Goo Taeg, Kim Kyu-Won
Abstract excerpt
Heat shock protein (Hsp)70 is a molecular chaperone that maintains protein homoeostasis during cellular stress through two opposing mechanisms: protein refolding and degradation. However, the mechanisms by which Hsp70 balances these opposing functions under stress conditions remain unknown. Here, we demonstrate that Hsp70 preferentially facilitates protein refolding after stress, gradually switching to protein...
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