Article
Activator protein 1 suppresses antitumor T-cell function via the induction of programmed death 1.
Proceedings of the National Academy of Sciences of the United States of America - 18 Sept 2012
Xiao Gang, Deng Anqi, Liu Haifeng, Ge Gaoxiang, Liu Xiaolong
Abstract excerpt
T cells play a critical role in tumor immunosurveillance by eliminating newly transformed somatic cells. However, tumor cell variants can escape from immunological control after immunoediting, leading to tumor progression. Whether and how T cells respond to tumor growth remain unclear. Here, we found that tumor-infiltrating T cells exhibited persistently up-regulated expression of the activator protein 1 (AP-1)...
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