Article
Combinations of cytochrome P-450 genotypes and risk of early-onset lung cancer in Caucasians and African Americans: a population-based study.
Lung cancer (Amsterdam, Netherlands) - 1 Mar 2007
Cote M L, Wenzlaff A S, Bock C H, Land S J, Santer S K, Schwartz D R, Schwartz A G
Abstract excerpt
Polymorphisms in CYP1A1 and CYP1B1 genes in humans are associated with reduction of enzymatic activity towards several substrates, including those found in tobacco smoke. To investigate the potential role these polymorphisms have as modulators of early-onset lung cancer risk, a population-based case-control study involving early-onset lung cancer cases was performed. Biological samples were available for 383...
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