Article
Risk of non-small cell lung cancer and the cytochrome P4501A1 Ile462Val polymorphism.
Cancer causes & control : CCC - 1 Jun 2005
Larsen Jill Everland, Colosimo Maree Louise, Yang Ian Anthony, Bowman Rayleen, Zimmerman Paul Victor, Fong Kwun Meng
Abstract excerpt
OBJECTIVE: The Ile462Val substitution in the cytochrome P450 1A1 gene (CYP1A1) results in increased enzymatic activity. Preliminary data suggesting a link between this polymorphism and lung cancer risk in Caucasians are inconsistent, reflecting small sample sizes and the relatively low frequency of the variant. METHODS: The data set consisted of 1050 primary non-small cell lung cancer cases and 581 controls, a...
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