Article
Perspective on sequence evolution of microsatellite locus (CCG)n in Rv0050 gene from Mycobacterium tuberculosis.
BMC evolutionary biology - 31 Aug 2011
Qin Lianhua, Wang Jie, Zheng Ruijuan, Lu Junmei, Yang Hua, Liu Zhonghua, Cui Zhenling, Jin Ruiliang, Feng Yonghong, Hu Zhongyi
Abstract excerpt
BACKGROUND: The mycobacterial genome is inclined to polymerase slippage and a high mutation rate in microsatellite regions due to high GC content and absence of a mismatch repair system. However, the exact molecular mechanisms underlying microsatellite variation have not been fully elucidated. Here, we investigated mutation events in the hyper-variable trinucleotide microsatellite locus MML0050 located in the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.