Article
Phenotypic and global gene expression profile changes between low passage and high passage MIN-6 cells.
The Journal of endocrinology - 1 Dec 2006
O'Driscoll Lorraine, Gammell Patrick, McKiernan Eadaoin, Ryan Eoin, Jeppesen Per Bendix, Rani Sweta, Clynes Martin
Abstract excerpt
The long-term potential to routinely use replacement beta cells/islets as cell therapy for type 1 diabetes relies on our ability to culture such cells/islets, in vitro, while maintaining their functional status. Previous beta cell studies, by ourselves and other researchers, have indicated that the glucose-stimulated insulin secretion (GSIS) phenotype is relatively unstable, in long-term culture. This study aimed...
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