Article
Clonal insulinoma cell line that stably maintains correct glucose responsiveness.
Diabetes - 1 Dec 1994
Knaack D, Fiore D M, Surana M, Leiser M, Laurance M, Fusco-DeMane D, Hegre O D, Fleischer N, Efrat S
Abstract excerpt
A number of pancreatic beta-tumor cell (beta TC) lines have been derived from insulinomas arising in transgenic mice expressing the SV40 T antigen gene under control of the insulin promoter. Some of these lines secrete insulin in response to physiological glucose concentrations. However, this phenotype is unstable. After propagation in culture, these nonclonal lines become responsive to subphysiological glucose...
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