Article
Clonal insulinoma cell line that stably maintains correct glucose responsiveness.
Diabetes - 1 Dec 1994
Knaack D, Fiore D M, Surana M, Leiser M, Laurance M, Fusco-DeMane D, Hegre O D, Fleischer N, Efrat S
Abstract excerpt
A number of pancreatic beta-tumor cell (beta TC) lines have been derived from insulinomas arising in transgenic mice expressing the SV40 T antigen gene under control of the insulin promoter. Some of these lines secrete insulin in response to physiological glucose concentrations. However, this phe...
Topics
- Animals
- Antigens, Polyomavirus Transforming
- Base Sequence
- Cell Line, Transformed
- Clone Cells
- Glucokinase
- Glucose
- Glucose Transporter Type 1
- Glucose Transporter Type 2
- Hexokinase
- Insulin
- Insulinoma
- Islets of Langerhans
- Mice
- Mice, Transgenic
- Microscopy, Electron
- Molecular Sequence Data
- Monosaccharide Transport Proteins