Article
Long-term passage impacts human dental pulp stem cell activities and cell response to drug addition in vitro
23 Aug 2024
Abstract excerpt
Background Dental pulp stem cells (DPSCs) possess mesenchymal stem cell characteristics and have potential for cell-based therapy. Cell expansion is essential to achieve sufficient cell numbers. However, continuous cell replication causes cell aging in vitro , which usually accompanies and potentially affect DPSC characteristics and activities. Continuous passaging could alter susceptibility to external factors...
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