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In Vitro Proliferation of Adult Human Beta-Cells

26 Apr 2012

Abstract excerpt

A decrease in functional beta-cell mass is a key feature of type 2 diabetes. Glucagon-like peptide 1 (GLP-1) analogues induce proliferation of rodent beta-cells. However, the proliferative capacity of human beta-cells and its modulation by GLP-1 analogues remain to be fully investigated. We therefore sought to quantify adult human beta-cell proliferation in vitro and whether this is affected by the GLP-1 analogue...

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PMID: 22563404
DOI: 10.1371/journal.pone.0035801

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