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Article

In vitro-cultured human islet cell monolayers: stemness markers and insulin recovery upon streptozotocin exposure.

Tissue engineering. Part A - 1 Dec 2009

Montanucci Pia, Basta Giuseppe, Calafiore Riccardo

Abstract excerpt

We have investigated long-term in vitro-cultured human islet-derived cell monolayers (CM) to determine their suitability as source of newly generated beta-cells. Initial loss of the islet three-dimensional architecture resulted in rearrangement of pancreatic hormone and key transcriptional factor expression, or decreased insulin secretion, or declined glucose-stimulated insulin release, reflecting reversal to an...

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Source

Identifiers

PMID: 19566440
DOI: 10.1089/ten.TEA.2009.0124

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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