Article
Effects of streptozotocin on in vitro long-term cultured human islet cell monolayers.
Transplantation proceedings - 1 Mar 2008
Montanucci P, Basta G, Racanicchi L, Calafiore R
Abstract excerpt
Replacement beta cells may be generated from stem/progenitor cells, possibly residing within the pancreatic islet cells. We sought to investigate the possible use of human islet (HI)-derived cell monolayers as a possible source for beta cells. These cells could be propagated in vitro and potentially induced to acquire glucose-stimulated insulin release (GSIR) ability. Loss of three-dimensional architecture,...
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