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Article

Alzheimer's presenilin 1 causes chromosome missegregation and aneuploidy.

Neurobiology of aging - 1 Mar 2008

Boeras Debrah I, Granic Antoneta, Padmanabhan Jaya, Crespo Nichole C, Rojiani Amyn M, Potter Huntington

Abstract excerpt

Mutations in the presenilin 1 gene cause most early onset familial Alzheimer's disease (FAD). Here, we report that a defect in the cell cycle - improper chromosome segregation - can be caused by abnormal presenilin function and therefore may contribute to AD pathogenesis. Specifically we find that either over-expression or FAD mutation in presenilin 1 (M146L and M146V) leads to chromosome missegregation and...

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Identifiers

PMID: 17169464
DOI: 10.1016/j.neurobiolaging.2006.10.027
PMCID: PMC2692942

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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