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Article

Loss of neuronal cell cycle control as a mechanism of neurodegeneration in the presenilin-1 Alzheimer's disease brain.

Cell cycle (Georgetown, Tex.) - 1 Mar 2008

Malik Bilal, Currais Antonio, Andres Ana, Towlson Christopher, Pitsi Didier, Nunes Ana, Niblock Michael, Cooper Jonathan, Hortobágyi Tibor, Soriano Salvador

Abstract excerpt

Presenilin-1 (PS1) is a component of the beta-catenin degradation machinery, and PS1 mutations linked to familial Alzheimer's disease (FAD) represent a loss of this function, leading, in non-neuronal cells, to accumulation of cyclin D1, aberrant cell cycle activation and hyperproliferation. In po...

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Identifiers

PMID: 18239458
DOI: 10.4161/cc.7.5.5427

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18239458-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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