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Chromosome missegregation and trisomy 21 mosaicism in Alzheimer's disease.

Neurobiology of disease - 1 Jun 1999

Geller L N, Potter H

Abstract excerpt

A connection between Alzheimer's disease (AD) and Down syndrome (trisomy 21) is indicated by the fact that all Down syndrome individuals develop Alzheimer's disease neuropathology by the 4th decade of life. Previous studies have examined the frequency of aneuploidy and other chromosomal defects in cells from familial Alzheimer's disease (FAD) patients, with varying results. To investigate the possibility that a...

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Identifiers

PMID: 10408806
DOI: 10.1006/nbdi.1999.0236

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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