Article

Molecular basis of mitotic decline during human aging

2018-02-06

Abstract excerpt

Aneuploidy, an abnormal chromosome number, has been linked to aging and age-associated diseases, but the underlying molecular mechanisms remain unknown. Supported by direct live-cell imaging of young, middle-aged and old-aged primary human dermal fibroblasts, we found that aneuploidy increases with aging due to general dysfunction of the mitotic machinery. Increased chromosome segregation defects in elderly mitoti...

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Literature Corpus work: f7be68a3-5a55-5e3a-9618-9951ec9777fa
DOI: 10.1101/261008

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