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Article

Chromosome Instability, Aging and Brain Diseases.

Cells - 19 May 2021

Iourov Ivan Y, Yurov Yuri B, Vorsanova Svetlana G, Kutsev Sergei I

Abstract excerpt

Chromosome instability (CIN) has been repeatedly associated with aging and progeroid phenotypes. Moreover, brain-specific CIN seems to be an important element of pathogenic cascades leading to neurodegeneration in late adulthood. Alternatively, CIN and aneuploidy (chromosomal loss/gain) syndromes exhibit accelerated aging phenotypes. Molecularly, cellular senescence, which seems to be mediated by CIN and...

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PMID: 34069648
DOI: 10.3390/cells10051256
PMCID: PMC8161106

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