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Article

Cerebrospinal fluid B cells from multiple sclerosis patients are subject to normal germinal center selection.

Journal of neuroimmunology - 1 Feb 2007

Harp Christopher, Lee Jane, Lambracht-Washington Doris, Cameron Elizabeth, Olsen Gregory, Frohman Elliot, Racke Michael, Monson Nancy

Abstract excerpt

Previous findings from our laboratory demonstrated that some clonally expanded cerebrospinal fluid (CSF) B cells from MS patients exhibit diminished mutation targeting patterns in comparison to typical B cells selected in the context of germinal centers (GCs). In order to determine whether the overall CSF B cell repertoires adhered to mutation patterns typical of GC-selected B cells, we analyzed the...

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Share to B-Lymphocytes
Share to Gene Rearrangement, B-Lymphocyte

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, Immunoglobulin

Share to Germinal Center

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Share to Nervous System Diseases

Share to Receptors, Antigen, B-Cell

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Source

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Identifiers

PMID: 17169437
DOI: 10.1016/j.jneuroim.2006.10.020
PMCID: PMC2034205

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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