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Article

In multiple sclerosis, oligoclonal bands connect to peripheral B‐cell responses

21 Dec 2013

Abstract excerpt

OBJECTIVE: To determine to what extent oligoclonal band (OCB) specificities are clonally interrelated and to what degree they are associated with corresponding B-cell responses in the peripheral blood (PB) of multiple sclerosis (MS) patients. METHODS: Mass-spectrometric proteomic analysis of isoelectric focused (IEF) cerebrospinal fluid (CSF) immunoglobulin G (IgG) was used in combination with next-generation...

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PMID: 24375699
DOI: 10.1002/ana.24088

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