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Article

Cerebrospinal-fluid-derived immunoglobulin G of different multiple sclerosis patients shares mutated sequences in complementarity determining regions.

Molecular & cellular proteomics : MCP - 1 Dec 2013

Singh Vaibhav, Stoop Marcel P, Stingl Christoph, Luitwieler Ronald L, Dekker Lennard J, van Duijn Martijn M, Kreft Karim L, Luider Theo M, Hintzen Rogier Q

Abstract excerpt

B lymphocytes play a pivotal role in multiple sclerosis pathology, possibly via both antibody-dependent and -independent pathways. Intrathecal immunoglobulin G in multiple sclerosis is produced by clonally expanded B-cell populations. Recent studies indicate that the complementarity determining regions of immunoglobulins specific for certain antigens are frequently shared between different individuals. In this...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 23970564
DOI: 10.1074/mcp.M113.030346
PMCID: PMC3861734

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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