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Article

The B cell response in multiple sclerosis

1 Apr 2006

Abstract excerpt

Multiple sclerosis (MS) plaques and CSF contain increased amounts of intrathecally synthesized IgG, manifest as oligoclonal bands (OCBs) after protein electrophoresis. OCBs are not unique to MS and are also produced in infectious diseases of the CNS, in which the oligoclonal IgG has been shown to be antibody directed against the disease-causing agent. Thus, analysis of antibody specificity may identify the...

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PMID: 16687047
DOI: 10.1179/016164106x98099

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