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Article

Potential of a unique antibody gene signature to predict conversion to clinically definite multiple sclerosis.

Journal of neuroimmunology - 18 Aug 2009

Cameron Elizabeth M, Spencer Sade, Lazarini Jonathan, Harp Christopher T, Ward E Sally, Burgoon Mark, Owens Gregory P, Racke Michael K, Bennett Jeffrey L, Frohman Elliot M, Monson Nancy L

Abstract excerpt

We identified a unique antibody gene mutation pattern (i.e. "signature") in cerebrospinal fluid (CSF) B cells from multiple sclerosis (MS) patients not present in control populations. Prevalence of the signature in CSF B cells of patients at risk to develop MS predicted conversion to MS with 91%...

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Identifiers

PMID: 19631394
DOI: 10.1016/j.jneuroim.2009.05.014
PMCID: PMC2785005

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19631394-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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