Article
Intrathecal B-cell clonal expansion, an early sign of humoral immunity, in the cerebrospinal fluid of patients with clinically isolated syndrome suggestive of multiple sclerosis.
Laboratory investigation; a journal of technical methods and pathology - 1 Jul 2003
Qin Yufen, Duquette Pierre, Zhang Yiping, Olek Michael, Da Reng-Rong, Richardson John, Antel Jack P, Talbot Pierre, Cashman Neil R, Tourtellotte Wallace W, Wekerle Hartmut, Van Den Noort Stanley
Abstract excerpt
The development of somatically mutated memory and plasma B cells is a consequence of T cell-dependent antigen-challenged humoral immunity. To investigate the role of B cell-mediated humoral immunity in the initiation and evolution of multiple sclerosis (MS), we analyzed Ig variable heavy chain genes of intrathecal B cells derived from patients with a first clinical manifestation suggestive of MS. Sequences of Ig...
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