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Article

Activation of phosphatidylinositol 3-kinase signaling by a mutant thyroid hormone beta receptor.

Proceedings of the National Academy of Sciences of the United States of America - 7 Feb 2006

Furuya Fumihiko, Hanover John A, Cheng Sheue-yann

Abstract excerpt

Activation of the phosphatidylinositol 3-kinase (PI3K)-AKT/protein kinase B signaling pathway has been associated with multiple human cancers. Recently we showed that AKT is activated in both the thyroid and metastatic lesions of a mouse model of follicular thyroid carcinoma [thyroid hormone beta receptor (TRbeta)(PV/PV) mice]. This TRbeta(PV/PV) mouse harbors a knock-in mutant TRbeta gene (TRbetaPV mutant) that...

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Identifiers

PMID: 16446424
DOI: 10.1073/pnas.0510849103
PMCID: PMC1413672

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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