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Article

The role of T-type calcium channels in epilepsy and pain.

Current pharmaceutical design - 1 Jan 2006

Nelson M T, Todorovic S M, Perez-Reyes E

Abstract excerpt

T-type calcium channels open in response to small depolarizations of the plasma membrane. The entry of two positive charges with every calcium ion leads to a further depolarization of the membrane, the low threshold spike, and opening of channels that have a higher threshold. In this manner, T-channels play an important pacemaker role in gating the activity of Na+ and Ca2+ channels. T-channels are preferentially...

Topics

Analgesics
Anesthetics
Animals
Anticonvulsants
Brain
Calcium
Calcium Channel Blockers
Calcium Channels, T-Type
Epilepsy
Humans
Mutation
Nociceptors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Pain

Pain Measurement

Protein Conformation

Source

Identifiers

PMID: 16787249
DOI: 10.2174/138161206777585184

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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