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Article

Calcium restores a normal proliferation phenotype in human polycystic kidney disease epithelial cells.

Journal of the American Society of Nephrology : JASN - 1 Jan 2006

Yamaguchi Tamio, Hempson Scott J, Reif Gail A, Hedge Anne-Marie, Wallace Darren P

Abstract excerpt

Polycystic kidney disease (PKD) is a lethal disorder characterized by progressive expansion of renal cysts. Genetic mutations associated with PKD are thought to disrupt intracellular Ca2+ regulation, leading to abnormal proliferation of tubule epithelial cells. cAMP stimulates the B-Raf/MEK/extracellular signal-regulated kinase (B-Raf/MEK/ERK) pathway and accelerates the proliferation of cells that are cultured...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16319189
DOI: 10.1681/ASN.2005060645

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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