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Article

A tubule cell line established from transgenic mice harboring temperature-sensitive simian virus 40 large T-antigen gene.

Japanese journal of cancer research : Gann - 1 Dec 1991

Yanai N, Satoh T, Kyo S, Abe K, Suzuki M, Obinata M

Abstract excerpt

Immortalization of cell lines with specific functions is important for examination of organ-specific functions in vitro. We established a kidney tubule cell line (TKC2) exhibiting a specific physiological response to hormone from the primary culture of kidneys of adult transgenic mice harboring temperature-sensitive SV40 large T-antigen gene. TKC2 cells showed temperature-sensitive growth in culture and exhibited...

Topics

Animals
Antigens, Viral, Tumor
Cell Line, Transformed
Cell Transformation, Viral
Cyclic AMP
Genes, Viral
Kidney Tubules
Mice
Mice, Inbred C57BL
Mice, Transgenic
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Simian virus 40

Stimulation, Chemical

Temperature

Vasopressins

Source

Open in PubMed Open full text

Identifiers

PMID: 1663919
DOI: 10.1111/j.1349-7006.1991.tb01803.x
PMCID: PMC5918353

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1663919-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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