Isolation and genetic characterization of a renal epithelial cell mutant defective in vasopressin (V2) receptor binding and function.

doi:10.1016/0014-4827(91)90399-f

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Isolation and genetic characterization of a renal epithelial cell mutant defective in vasopressin (V2) receptor binding and function.

Experimental cell research - 1 Aug 1991

Luzius H, Jans D A, Jans P, Fahrenholz F

Abstract excerpt

A novel mutant of the LLC-PK1 renal epithelial cell line, VPR1, was isolated after mutagenesis with N-methyl-N'-nitro-N-nitrosoguanidine and selection using a photoactivatable vasopressin analogue [1-(3-mercapto)propionic acid, 8-(N6-4-azidophenylamidino)lysine] vasopressin. The VPR1 mutant cell line possessed less than 5% parental V2 receptor binding for vasopressin but exhibited normal calcitonin receptor...

Topics

Adenylyl Cyclases
Animals
Cell Line
Cyclic AMP
Epithelial Cells
Epithelium
Fibrinolytic Agents
Hybrid Cells
Kidney
Methylnitronitrosoguanidine
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Plasminogen Activators

Receptors, Angiotensin

Receptors, Vasopressin

Swine

Urokinase-Type Plasminogen Activator

Vasopressins

Source

Open in PubMed

Identifiers

PMID: 1649058
DOI: 10.1016/0014-4827(91)90399-f

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1649058-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Isolation and genetic characterization of a renal epithelial cell mutant defective in vasopressin (V2) receptor binding and function.PMID 1649058Read ↗

A system to select for mutant LLC-PK1 cells affected in cAMP mediated hormonal response using a photoactivatable analogue of vasopressin.Semantic proximity Read ↗

Vasopressin receptor 2 mutations in the nephrogenic syndrome of inappropriate antidiuresis show different mechanisms of constitutive activation for G protein coupled receptors.Semantic proximity Read ↗

Misfolded vasopressin V2 receptors caused by extracellular point mutations entail congential nephrogenic diabetes insipidus.Semantic proximity Read ↗

Development and characterization of a mouse cell line expressing the human V2 vasopressin receptor gene.Semantic proximity Read ↗

Functional characterization of five V2 vasopressin receptor gene mutations.Semantic proximity Read ↗

Two vasopressin type 2 receptor gene mutations R143P and delta V278 in patients with nephrogenic diabetes insipidus impair ligand binding of the receptor.Semantic proximity Read ↗

The effect of eight V2 vasopressin receptor mutations on stimulation of adenylyl cyclase and binding to vasopressin.Semantic proximity Read ↗

Monensin-resistant LLC-PK1 cell mutants are affected in recycling of the adenylate cyclase-stimulating vasopressin V2-receptor.Semantic proximity Read ↗

Functional rescue of vasopressin V2 receptor mutants in MDCK cells by pharmacochaperones: relevance to therapy of nephrogenic diabetes insipidus.Semantic proximity Read ↗

Biochemical basis of partial nephrogenic diabetes insipidus phenotypes.Semantic proximity Read ↗

Molecular cloning, sequencing, and functional expression of a cDNA encoding the human V1a vasopressin receptor.Semantic proximity Read ↗

Functional vasopressin V1 type receptors are present in variant as well as classical forms of small-cell carcinoma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.