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Article

The Drosophila Arf GEF Steppke controls MAPK activation in EGFR signaling.

Journal of cell science - 1 Jun 2013

Hahn Ines, Fuss Bernhard, Peters Annika, Werner Tamara, Sieberg Andrea, Gosejacob Dominic, Hoch Michael

Abstract excerpt

Guanine nucleotide exchange factors (GEFs) of the cytohesin protein family are regulators of GDP/GTP exchange for members of the ADP ribosylation factor (Arf) of small GTPases. They have been identified as modulators of various receptor tyrosine kinase signaling pathways including the insulin, the vascular epidermal growth factor (VEGF) and the epidermal growth factor (EGF) pathways. These pathways control many...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23549788
DOI: 10.1242/jcs.120964

Genes

EGFR
EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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