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Article

Conserved MicroRNA miR-8/miR-200 and its target USH/FOG2 control growth by regulating PI3K.

Cell - 11 Dec 2009

Hyun Seogang, Lee Jung Hyun, Jin Hua, Nam JinWu, Namkoong Bumjin, Lee Gina, Chung Jongkyeong, Kim V Narry

Abstract excerpt

How body size is determined is a long-standing question in biology, yet its regulatory mechanisms remain largely unknown. Here, we find that a conserved microRNA miR-8 and its target, USH, regulate body size in Drosophila. miR-8 null flies are smaller in size and defective in insulin signaling in fat body that is the fly counterpart of liver and adipose tissue. Fat body-specific expression and clonal analyses...

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PMID: 20005803
DOI: 10.1016/j.cell.2009.11.020

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