Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Modeling complex genetic interactions in a simple eukaryotic genome: actin displays a rich spectrum of complex haploinsufficiencies.

Genes & development - 15 Jan 2007

Haarer Brian, Viggiano Susan, Hibbs Mathew A, Troyanskaya Olga G, Amberg David C

Abstract excerpt

Multigenic influences are major contributors to human genetic disorders. Since humans are highly polymorphic, there are a high number of possible detrimental, multiallelic gene pairs. The actin cytoskeleton of yeast was used to determine the potential for deleterious bigenic interactions; approximately 4800 complex hemizygote strains were constructed between an actin-null allele and the nonessential gene deletion...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Actins
Share to Endocytosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Deletion

Share to Genome, Fungal

Share to Microfilament Proteins

Share to Multifactorial Inheritance

Share to Ribosomes

Share to Saccharomyces cerevisiae Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 17167106
DOI: 10.1101/gad.1477507
PMCID: PMC1770898

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Modeling complex genetic interactions in a simple eukaryotic genome: actin displays a rich spectrum of complex haploinsufficiencies.PMID 17167106Read ↗

Novel interactions between actin and the proteasome revealed by complex haploinsufficiency.Semantic proximity Read ↗

Linking genetics to structural biology: complex heterozygosity screening with actin alanine scan alleles identifies functionally related surfaces on yeast actin.Semantic proximity Read ↗

Hierarchical organization of the human cell from a cancer coessentiality networkSemantic proximity Read ↗

Evolutionary plasticity of genetic interaction networks.Semantic proximity Read ↗

Systematic analysis of complex genetic interactions.Semantic proximity Read ↗

A global genetic interaction map of a human cell reveals conserved principles of genetic networksSemantic proximity Read ↗

The genotype-phenotype map of yeast complex traits: basic parameters and the role of natural selection.Semantic proximity Read ↗

High-resolution mapping of complex traits with a four-parent advanced intercross yeast population.Semantic proximity Read ↗

Genotype to phenotype: a complex problem.Semantic proximity Read ↗

Systematic Humanization of the Yeast Cytoskeleton Discerns Functionally Replaceable from Divergent Human Genes.Semantic proximity Read ↗

High-dimensional single-cell phenotyping reveals extensive haploinsufficiency.Semantic proximity Read ↗

Combining genome sequences and new technologies for dissecting the genetics of complex phenotypes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.