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Article

Novel interactions between actin and the proteasome revealed by complex haploinsufficiency.

PLoS genetics - 1 Sept 2011

Haarer Brian, Aggeli Dimitra, Viggiano Susan, Burke Daniel J, Amberg David C

Abstract excerpt

Saccharomyces cerevisiae has been a powerful model for uncovering the landscape of binary gene interactions through whole-genome screening. Complex heterozygous interactions are potentially important to human genetic disease as loss-of-function alleles are common in human genomes. We have been using complex haploinsufficiency (CHI) screening with the actin gene to identify genes related to actin function and as a...

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Identifiers

PMID: 21966278
DOI: 10.1371/journal.pgen.1002288
PMCID: PMC3178594

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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