Article

Aberrant ciliogenesis induced by enhanced BMP signaling causes heterotopic ossification

2026-07-03

Abstract excerpt

Bone morphogenetic protein (BMP) signaling is a principal driver of heterotopic ossification (HO), yet how aberrant BMP activity structurally reprograms cellular signaling machinery to develop HO remains unclear. Here, we identify BMP signaling as a direct upstream regulator of ciliogenesis that coordinates a multi-stage, pro-osteochondrogenic signaling relay during HO. Using a conditional gain-of-function BMP mou...

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Literature Corpus work: daa3d65e-769c-5ba7-b8cb-5bc6833d13b7
DOI: 10.64898/2026.07.02.735922

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