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Article

Canonical and noncanonical intraflagellar transport regulates craniofacial skeletal development

26 Apr 2016

Abstract excerpt

The primary cilium is a cellular organelle that coordinates signaling pathways critical for cell proliferation, differentiation, survival, and homeostasis. Intraflagellar transport (IFT) plays a pivotal role in assembling primary cilia. Disruption and/or dysfunction of IFT components can cause multiple diseases, including skeletal dysplasia. However, the mechanism by which IFT regulates skeletogenesis remains...

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PMID: 27118846
DOI: 10.1073/pnas.1519458113

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