Article
Human leukocyte antigen-E mismatch is associated with better hematopoietic stem cell transplantation outcome in acute leukemia patients.
Haematologica - 1 Nov 2017
Tsamadou Chrysanthi, Fürst Daniel, Vucinic Vladan, Bunjes Donald, Neuchel Christine, Mytilineos Daphne, Gramatzki Martin, Arnold Renate, Wagner Eva Maria, Einsele Hermann, Müller Carlheinz, Schrezenmeier Hubert, Mytilineos Joannis
Abstract excerpt
The immunomodulatory role of human leukocyte antigen (HLA)-E in hematopoietic stem cell transplantation (HSCT) has not been extensively investigated. To this end, we genotyped 509 10/10 HLA unrelated transplant pairs for HLA-E, in order to study the effect of HLA-E as a natural killer (NK)-alloreactivity mediator on HSCT outcome in an acute leukemia (AL) setting. Overall survival (OS), disease free survival...
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