Article
Decreased Soluble Human Leukocyte Antigen E Levels in Patients After Allogeneic Hematopoietic Stem Cell Transplantation Are Associated With Severe Acute and Extended Chronic Graft-versus-Host Disease and Inferior Overall Survival.
Frontiers in immunology - 1 Jan 2019
Kordelas Lambros, Schwich Esther, Lindemann Monika, Heinemann Falko M, Buttkereit Ulrike, Horn Peter A, Beelen Dietrich W, Rebmann Vera
Abstract excerpt
HLA-E is a member of the non-classical HLA molecules and by interaction with activating or inhibitory receptors of NK and T cells, HLA-E can lead to immune activation or suppression context-dependently. Recently, the non-classical HLA molecules gain more attention in the setting of allogeneic hematopoietic stem cell transplantation (HSCT). Most studies so far have focused on the two most frequent genotypes...
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