Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Elongation arrest is a physiologically important function of signal recognition particle.

The EMBO journal - 1 Aug 2000

Mason N, Ciufo L F, Brown J D

Abstract excerpt

Signal recognition particle (SRP) targets proteins for co-translational insertion through or into the endoplasmic reticulum membrane. Mammalian SRP slows nascent chain elongation by the ribosome during targeting in vitro. This 'elongation arrest' activity requires the SRP9/14 subunit of the particle and interactions of the C-terminus of SRP14. We have purified SRP from Saccharomyces cerevisiae and demonstrated...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biological Transport
Share to Cell Compartmentation
Share to Peptide Chain Elongation, Translational

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to RNA-Binding Proteins

Share to Saccharomyces cerevisiae

Share to Saccharomyces cerevisiae Proteins

Share to Sequence Deletion

Share to Signal Recognition Particle

Source

Open in PubMed Open full text

Identifiers

PMID: 10921896
DOI: 10.1093/emboj/19.15.4164
PMCID: PMC306590

Genes

SRP14
SRP9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Elongation arrest is a physiologically important function of signal recognition particle.PMID 10921896Read ↗

The signal recognition particle in S. cerevisiae.Semantic proximity Read ↗

SRP samples nascent chains for the presence of signal sequences by interacting with ribosomes at a discrete step during translation elongation.Semantic proximity Read ↗

Translational Control of Secretory Proteins in Health and Disease.Semantic proximity Read ↗

Access to ribosomal protein Rpl25p by the signal recognition particle is required for efficient cotranslational translocation.Semantic proximity Read ↗

Sls1p, an endoplasmic reticulum component, is involved in the protein translocation process in the yeast Yarrowia lipolytica.Semantic proximity Read ↗

Signal recognition particle receptor is important for cell growth and protein secretion in Saccharomyces cerevisiae.Semantic proximity Read ↗

Genetic and biochemical analysis of the fission yeast ribonucleoprotein particle containing a homolog of Srp54p.Semantic proximity Read ↗

A complex of the signal sequence binding protein and the SRP RNA promotes translocation of nascent proteins.Semantic proximity Read ↗

SRP RNA provides the physiologically essential GTPase activation function in cotranslational protein targeting.Semantic proximity Read ↗

An interaction between the SRP receptor and the translocon is critical during cotranslational protein translocation.Semantic proximity Read ↗

Uncoupling of GTP hydrolysis from eIF6 release on the ribosome causes Shwachman-Diamond syndrome.Semantic proximity Read ↗

Translation arrest requires two-way communication between a nascent polypeptide and the ribosome.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.