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Article

Studies of in vivo mutations in rpsL transgene in UVB-irradiated epidermis of XPA-deficient mice.

Mutation research - 30 May 2000

Murai H, Takeuchi S, Nakatsu Y, Ichikawa M, Yoshino M, Gondo Y, Katsuki M, Tanaka K

Abstract excerpt

We have established xeroderma pigmentosum group A (XPA) gene-knockout mice with nucleotide excision repair (NER) deficiency, which rapidly developed skin tumors when exposed to a low dose of chronic UV like XP-A patients, confirming that the NER process plays an important role in preventing UVB-induced skin cancer. To examine the in vivo mutation in the UVB-irradiated epidermis, we established XPA (-/-), (+/-)...

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Source

Identifiers

PMID: 10838142
DOI: 10.1016/s0027-5107(00)00024-5

Genes

XPA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Studies of in vivo mutations in rpsL transgene in UVB-irradiated epidermis of XPA-deficient mice.PMID 10838142Read ↗

UV-induced skin carcinogenesis in xeroderma pigmentosum group A (XPA) gene-knockout mice with nucleotide excision repair-deficiency.Semantic proximity Read ↗

Mutation spectrum in UVB-exposed skin epidermis of Xpa-knockout mice: frequent recovery of triplet mutations.Semantic proximity Read ↗

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Mutagenicity Profile Induced by UVB Light in Human Xeroderma Pigmentosum Group C Cells.Semantic proximity Read ↗

Additive roles of XPA and MSH2 genes in UVB-induced skin tumorigenesis in mice.Semantic proximity Read ↗

Persistence of p53 mutations and resistance of keratinocytes to apoptosis are associated with the increased susceptibility of mice lacking the XPC gene to UV carcinogenesis.Semantic proximity Read ↗

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