Article
Mutation spectrum in UVB-exposed skin epidermis of a mildly-affected Xpg-deficient mouse.
Environmental and molecular mutagenesis - 1 Mar 2006
Wang Feng, Saito Yusuke, Shiomi Tadahiro, Yamada Shogo, Ono Tetsuya, Ikehata Hironobu
Abstract excerpt
A C-terminal 183 amino acid-truncated mutation of the mouse Xpg gene (XpgDeltaex15) gives rise to a partial deficiency in nucleotide excision repair in homozygously affected cells. We studied the effect of this mutation on UVB-induced mutagenesis in mouse skin, using transgenic mice harboring lambda-phage-based bacterial lacZ genes as a mutational reporter. UVB increased the lacZ mutant frequency in the epidermis...
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