Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Analysis of mutation spectra in UVB-exposed mouse skin epidermis and dermis: frequent occurrence of C-->T transition at methylated CpG-associated dipyrimidine sites.

Environmental and molecular mutagenesis - 1 Jan 2003

Ikehata Hironobu, Masuda Toshinari, Sakata Hiroyuki, Ono Tetsuya

Abstract excerpt

We recently reported the kinetics of mutation induction by UVB in the skin epidermis and dermis of transgenic Muta trade mark mice [Ikehata and Ono, Mutat Res 508:41-47, 2002]. In the present study we determined the complete DNA sequence of the lacZ transgene in 208 mutants isolated from the dermis and epidermis of UVB-irradiated and control mice. The resulting mutation patterns for the dermis and epidermis were...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Sequence
Share to CpG Islands

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Methylation

Share to DNA Primers

Share to Lac Operon

Share to Ultraviolet Rays

Source

Identifiers

PMID: 12717783
DOI: 10.1002/em.10153

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Analysis of mutation spectra in UVB-exposed mouse skin epidermis and dermis: frequent occurrence of C-->T transition at methylated CpG-associated dipyrimidine sites.PMID 12717783Read ↗

UVA induces C-->T transitions at methyl-CpG-associated dipyrimidine sites in mouse skin epidermis more frequently than UVB.Semantic proximity Read ↗

Mutation spectrum in sunlight-exposed mouse skin epidermis: small but appreciable contribution of oxidative stress-mediated mutagenesis.Semantic proximity Read ↗

Mutation spectrum in UVB-exposed skin epidermis of a mildly-affected Xpg-deficient mouse.Semantic proximity Read ↗

UVB-induced gpt mutations in the skin of gpt delta transgenic mice.Semantic proximity Read ↗

UVB-induced mutagenesis in hairless lambda lacZ-transgenic mice.Semantic proximity Read ↗

Involvement of 5-methylcytosine in sunlight-induced mutagenesis.Semantic proximity Read ↗

Mutation induction with UVB in mouse skin epidermis is suppressed in acute high-dose exposure.Semantic proximity Read ↗

Mutations induced by ultraviolet light.Semantic proximity Read ↗

Significance of CpG Methylation for Solar UV‐Induced Mutagenesis and Carcinogenesis in Skin<sup>‡</sup>Semantic proximity Read ↗

In Vivo Spectrum of UVC-induced Mutation in Mouse Skin Epidermis May Reflect the Cytosine Deamination Propensity of Cyclobutane Pyrimidine Dimers.Semantic proximity Read ↗

Distribution of spontaneous CpG-associated G:C --> A:T mutations in the lacZ gene of Muta mice: effects of CpG methylation, the sequence context of CpG sites, and severity of mutations on the activity of the lacZ gene product.Semantic proximity Read ↗

UVA1 genotoxicity is mediated not by oxidative damage but by cyclobutane pyrimidine dimers in normal mouse skin.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.