Proliferative, phenotypic and functional and molecular characteristics of tumour-infiltrating lymphocytes obtained from unselected patients with malignant melanomas and expanded in vitro in the presence of recombinant interleukin-2.

doi:10.1097/00008390-199404000-00007

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Article

Proliferative, phenotypic and functional and molecular characteristics of tumour-infiltrating lymphocytes obtained from unselected patients with malignant melanomas and expanded in vitro in the presence of recombinant interleukin-2.

Melanoma research - 1 Apr 1994

Melioli G, Guastella M, Semino C, Meta M, Pietra G, Ponte M, Queirolo P, Sertoli M R, Martini L, Reali U M

Abstract excerpt

Tumour-infiltrating lymphocytes (TIL) derived from several histotypes, including melanoma, can be expanded in vitro in the presence of recombinant interleukin-2 (rIL-2) and infused as part of experimental adoptive immunotherapy protocols. Several authors have described the isolation and the expan...

Topics

Adult
Cell Division
Cytotoxicity, Immunologic
Female
Humans
Immunotherapy, Adoptive
Interleukin-2
Lymphocyte Activation
Lymphocytes, Tumor-Infiltrating
Male
Melanoma
Middle Aged
Phenotype
Receptors, Antigen, T-Cell, alpha-beta

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Recombinant Proteins

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Identifiers

PMID: 8069098
DOI: 10.1097/00008390-199404000-00007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8069098-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.