Activation and in vitro expansion of tumor-reactive T lymphocytes from lymph nodes draining human primary breast cancers.

doi:10.1002/jso.2930460210

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Article

Activation and in vitro expansion of tumor-reactive T lymphocytes from lymph nodes draining human primary breast cancers.

Journal of surgical oncology - 1 Feb 1991

Hoover S K, Frank J L, McCrady C, McKinnon J G, Bear H D

Abstract excerpt

The feasibility of in vitro activation of lymphocytes from the draining lymph nodes (DLN) of breast cancer patients was examined. Lymphocytes isolated from 48 DLN from 12 patients were examined for their proliferative responses to rIL-2, autologous tumor cells, or rIL-2 plus tumor cells. Three ge...

Topics

Antigens, Neoplasm
Breast Neoplasms
Calcium
Cells, Cultured
Cytotoxicity, Immunologic
Female
Growth Substances
Humans
In Vitro Techniques
Interleukin-2
Ionomycin
Lymph Nodes
Lymphocyte Activation
Lymphocyte Culture Test, Mixed
Mitogens
Phenotype
Phorbol Esters
Protein Kinase C

Source

Open in PubMed

Identifiers

PMID: 1825123
DOI: 10.1002/jso.2930460210

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1825123-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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