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Article

Bcl-xl does not have to bind Bax to protect T cells from death.

The Journal of experimental medicine - 25 Dec 2006

Liu Xinqi, Zhu Yanan, Dai Shaodong, White Janice, Peyerl Fred, Kappler John W, Marrack Philippa

Abstract excerpt

Activated T cells die when antigen disappears from animals. This death is caused by proteins related to Bcl-2. Two hypotheses have been suggested to explain the actions of the different types of Bcl-2 proteins. One hypothesis suggests that, when T cells prepare to die, Bak and Bax, the proteins that actually kill activated T cells, are released from antiapoptotic proteins such as Bcl-2 and Bcl-xl. Another...

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Source

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Identifiers

PMID: 17158961
DOI: 10.1084/jem.20061151
PMCID: PMC2118172

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Bcl-xl does not have to bind Bax to protect T cells from death.PMID 17158961Read ↗

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Bax activation by engagement with, then release from, the BH3 binding site of Bcl-xL.Semantic proximity Read ↗

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