Article
Identification of a novel regulatory domain in Bcl-X(L) and Bcl-2.
The EMBO journal - 3 Mar 1997
Chang B S, Minn A J, Muchmore S W, Fesik S W, Thompson C B
Abstract excerpt
Bcl-X(L), a member of the Bcl-2 family, can inhibit many forms of programed cell death. The three-dimensional structure of Bcl-X(L) identified a 60 amino acid loop lacking defined structure. Although amino acid sequence within this region is not conserved among Bcl-2 family members, structural mo...
Topics
- Amino Acid Sequence
- Animals
- Apoptosis
- B-Lymphocytes
- Blotting, Western
- Cell Survival
- Cells, Cultured
- Clone Cells
- Dimerization
- Flow Cytometry
- Gene Expression
- Humans
- Mice
- Molecular Sequence Data
- Mutation
- Phosphorylation
- Precipitin Tests
- Proto-Oncogene Proteins