Article
Identification of a novel regulatory domain in Bcl-X(L) and Bcl-2.
The EMBO journal - 3 Mar 1997
Chang B S, Minn A J, Muchmore S W, Fesik S W, Thompson C B
Abstract excerpt
Bcl-X(L), a member of the Bcl-2 family, can inhibit many forms of programed cell death. The three-dimensional structure of Bcl-X(L) identified a 60 amino acid loop lacking defined structure. Although amino acid sequence within this region is not conserved among Bcl-2 family members, structural modeling suggested that Bcl-2 also contains a large unstructured region. Compared with the full-length protein, loop...
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